When you're working in a bigger company, there are around 500 people and a lots of projects from very different genre. For example I am now working in a Web Development project based on Angular. I do only CSS there, but I can read and find myself inside this project pretty easily.
The real knowledge of solving problems and debugging issues is transferable to any framework and even for different languages. The only criteria of choosing a framework for anyone wondering should be:
In the long term the only thing that matter is that everyone should become an expert in the area they choose and then try to broaden the knowledge to different subjects.
So don't spend more time than a few hours to think about choosing the hottest framework now. The best you can do is just pick anything and build something with it.
The basics and concepts are first, but it still good to learn a framework. It just doesn't matter which one you'll chose in the long term and I recommend using React, because I see how my skills with vanillajs have grown thanks to React
I actually recommend learning React if you aren't decided which framework to choose, but I just wanted to point it out that in the long term, it doesn't matter that much as you may think in the beginning. Mastering one will definitely make you a great programmer and will let you get familiar with another one much quicker?
If you have 0 interest in writing mobile apps- only web,it really doesn't matter, choose the one which gives you more opportunity for work
So go and build something!